Search results for "effects | decay | survival probability"
showing 10 items of 990 documents
Could PD-1/PDL1 immune checkpoints be linked to HLA signature?
2019
The outstanding clinical expansion of monoclonal antibodies (mAbs) to programmed cell death receptor-1 (PD-1) (nivolumab and pembrolizumab) and PD-1 ligand-1 (PDL-1) (atezolizumab, avelumab and durvalumab) has received an increasing level of interest regarding immunotherapy and multidrug combinations, for the treatment of a number of common human malignancies. Some patients treated with these agents receive remarkable benefits in term of quality of life, progression-free (PFS) and overall survival (OS). However, a significant percentage of these patients experience immune-related adverse events (irAEs), while others present with an ultra-rapid disease progression, defined as hyperprogressio…
Measurement of dielectron production in central Pb-Pb collisions at √sNN = 2.76 TeV
2019
Published by the American Physical Society under the terms of the Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI. The first measurement of dielectron (e + e −) production in central (0 – 10 %) Pb – Pb collisions at √sNN=2.76TeV at the LHC is presented. The dielectron invariant-mass spectrum is compared to the expected contributions from hadron decays in the invariant-mass range 0 < mee < 3.5 GeV / c2. The ratio of data and the cocktail of hadronic contributions without vacuum ρ0 is measured in the invariant-mass range 0.15 < mee < 0.7 GeV / c2, w…
SV40 transformed fibroblasts recognize the same 140 kD fibronectin chemotactic fragment as non-transformed cells
1985
SV40-virus-transformed human embryonal fibroblasts show an enhanced chemotactic response to the glycoprotein fibronectin. However, they recognize the same chemotactic active region as non-transformed fibroblasts. The result suggests that an enhancement of chemotaxis by fibroblasts which have been transformed with Simian Virus 40 is due not to the utilization of further chemotactic domains in the molecule, but to an increased sensitivity of the cells to the chemoattractant.
Emission of Bromine and Iodine from Mt. Etna volcano
2005
Constraining fluxes of volcanic bromine and iodine to the atmosphere is important given the significant role these species play in ozone depletion. However, very few such measurements have been made hitherto, such that global volcanic fluxes are poorly constrained. Here we extend the data set of volcanic Br and I degassing by reporting the first measurements of bromine and iodine emissions from Mount Etna. These data were obtained using filter packs and contemporaneous ultraviolet spectroscopic SO2 flux measurements, resulting in time-averaged emission rates of 0.7 kt yr(-1) and 0.01 kt yr(-1) for Br and I, respectively, from April to October 2004, from which we estimate global Br and I flu…
A Comparative Eye Tracking Study of Usability—Towards Sustainable Web Design
2021
Websites are one of the most frequently used communication environments, and creating sustainable web designs should be an objective for all companies. Ensuring high usability is proving to be one of the main contributors to sustainable web design, reducing usage time, eliminating frustration and increasing satisfaction and retention. The present paper studies the usability of different website landing pages, seeking to identify the elements, structures and designs that increase usability. The study analyzed the behavior of 22 participants during their interaction with five different landing pages while they performed three tasks on the webpage and freely viewed each page for one minute. Th…
Kilka uwag o skutkach odstąpienia od umowy
2018
The MIMOSE Approach to Support Sustainable Forest Management Planning at Regional Scale in Mediterranean Contexts
2017
In recent decades, Mediterranean landscapes have been affected by human-induced drivers, such as land use and climate change. Forest ecosystems and landscapes have been particularly affected in mountainous regions due to limited management and stewardship, especially in remote areas. Therefore, there is a need to set up new strategies to enhance ecosystem services in forested areas which, in turn, will benefit local communities and economies. In this study, we implemented a new approach—Multiscale Mapping of Ecosystem Services (MIMOSE)—to assess ecosystem services in Mediterranean forests located in a mountainous region of Italy. We spatially assessed timber provision and carbon sequestrati…
The Relationship between Knowledge Characteristics’ Fit and Job Satisfaction and Job Performance: The Mediating Role of Work Engagement
2020
Knowledge workers are highly valued by organizations, but there is a lack of evidence about the role of work engagement in the satisfaction and performance of these workers. Harmonization and Person&ndash
Inspiriting Innovation: The Effects of Leader-Member Exchange (LMX) on Innovative Behavior as Mediated by Mindfulness and Work Engagement
2021
Continuous innovation has become a key to gaining a sustainable competitive advantage for organizations in the 21st century. By focusing on the underlying mechanisms (i.e., mindfulness and work engagement) by which it works, this study addresses the quality of leader–member relationships and their relevance for innovation in the workplace. Using a sample of 210 employees from 17 Spanish companies, a two-wave longitudinal design evaluated the mediational roles of mindfulness and engagement between leader–member exchange (LMX) quality and innovative work behavior (IWB) in an organizational context. Over the course of a year, two questionnaires were administered to measure LMX quality, mindful…
Search for the Decay of the Higgs Boson to Charm Quarks with the ATLAS Experiment
2018
A direct search for the standard model Higgs boson decaying to a pair of charm quarks is presented. Associated production of the Higgs and Z bosons, in the decay mode ZH→ℓ+ℓ−c¯c is studied. A data set with an integrated luminosity of 36.1 fb−1 of pp collisions at √s=13TeV recorded by the ATLAS experiment at the LHC is used. The H→c¯c signature is identified using charm-tagging algorithms. The observed (expected) upper limit on σ(pp→ZH)×B(H→c¯c) is 2.7 (3.9+2.1−1.1) pb at the 95% confidence level for a Higgs boson mass of 125 GeV, while the standard model value is 26 fb.